Near-infrared fl uorescence probe based on selective recognition of glutathione
Abstract
Glutathione (GSH) is an important bioactive molecule, and its content is closely related to the stability and health of the
intracellular environment. Therefore, the detection of GSH is of great signifi cance for life science research. Near-infrared fl uorescence probe
can eff ectively avoid fl uorescence quenching and enhance fl uorescence signal, so it is often used in the detection of GSH. In recent years,
the development of near-infrared fl uorescence probes has been rapid, and several series of near-infrared fl uorescence probes have been
reported for the detection of GSH. Based on this, a new type of NIR fl uorescence probe was designed and synthesized in this paper. Through
its recognition with glutathione (GSH), the fl uorescence of the probe was enhanced after reaction with glutathione. Because the probe has
selective recognition of GSH, high sensitivity and certain biocompatibility, it can be used for the detection of GSH content in vivo.
intracellular environment. Therefore, the detection of GSH is of great signifi cance for life science research. Near-infrared fl uorescence probe
can eff ectively avoid fl uorescence quenching and enhance fl uorescence signal, so it is often used in the detection of GSH. In recent years,
the development of near-infrared fl uorescence probes has been rapid, and several series of near-infrared fl uorescence probes have been
reported for the detection of GSH. Based on this, a new type of NIR fl uorescence probe was designed and synthesized in this paper. Through
its recognition with glutathione (GSH), the fl uorescence of the probe was enhanced after reaction with glutathione. Because the probe has
selective recognition of GSH, high sensitivity and certain biocompatibility, it can be used for the detection of GSH content in vivo.
Keywords
selective recognition; Glutathione; And near-infrared fl uorescent probes
Full Text:
PDFReferences
[1] Lina Huang. Near infrared fl uorescence probe for detection of ONOO- [J]. Chemical Engineering Management,2020(8):40-41. (in Chinese)
[2] Yunze Xu,Yusi Yao,Guanglei Lv, etal. A novel near-infrared fl uorescence probe for the detection of Aβ40 aggregates [J]. Chinese Journal of Luminescen
ce,2022,43(10):1620-1627.
[3] Minhuan Lan,E Pang,Shaojing Zhao, etal. [J]. Journal of Nanchang University (Science Edition),2022,46(5):534-542.
DOI: https://doi.org/10.18686/esta.v10i3.450
Refbacks
- There are currently no refbacks.
Copyright (c) 2023 Meiyan Wu
